Epidemiology and clinical impact of parainfluenza virus infections in otherwise healthy infants and young children < 5 years old.
نویسندگان
چکیده
Over a 20-year period in a population of otherwise healthy children, respiratory viruses have been cultured from nasal wash specimens from each child with a clinically significant respiratory illness. Since efforts are underway to develop vaccines for prevention of illness due to parainfluenza virus (PIV) type 3, the epidemiologic characteristics of PIVs were reviewed, and the population size necessary to demonstrate vaccine efficacy was estimated. A population of 1429 children was followed through early childhood. PIVs were isolated from 286 samples, 17.4% of positive viral cultures. PIV-3 was the most common: 10% of the children had at least one symptomatic, culture-proven PIV-3 infection. PIV-3 was endemic during the study period, while the other two PIVs, PIV-1 and -2, caused biennial flu epidemics. Only four PIV-related hospitalizations were seen. The efficacy of a PIV-3 vaccine could be demonstrated in a trial of 600 carefully monitored children vaccinated by 3 months and followed to 15 months of age.
منابع مشابه
تعیین فراوانی عفونت ویروسی پاراآنفلوآنزا به روش ایمونوفلوئورسانس در عفونتهای حاد تنفسی
Background: Acute respiratory tract infections, both bacterial and viral, cause 4.5 million childhood deaths worldwide, most of which occur in developing countries. Parainfluenza viruses, of the paramyxoviridae family, are among the common causes of acute respiratory infections, giving rise to 30% of respiratory infections in children before school age. The four parainfluenza viruses that cause...
متن کاملThe Frequency Distribution of Parainfluenza, Adeno and Respiratory Syncytial Virus Infections in Children below 2 Years Old with Bronchiolititis, by Multiplex Polymerase Chain Reaction Method, Afzalipoor Hospital, Kerman, 2006
Background & Aims: Acute respiratory infections are common cause of mortality during childhood. This study was designed to determine the incidence of adenovirus, parainfluenza virus and respiratory syncytial virus in respiratory infections by Multiplex PCR method. Methods: This study included 168 children under 2 years of age with clinical diagnosis of bronchiolitis. Nasopharyngeal specimens we...
متن کاملEpidemiological and clinical evaluation of children with respiratory virus infections
Background :Respiratory viruses are the leading cause of respiratory tract infections among children and are responsible for causing morbidity and mortality worldwide. This study was performed to detect viruses in children with respiratory infections and describe their epidemiology and clinical characteristics. Methods : In this descriptive cross sectional study, throat swabs and wash speci...
متن کاملHuman parainfluenza virus infection in severe acute respiratory infection cases in Beijing, 2014‐2016: A molecular epidemiological study
BACKGROUND Severe acute respiratory infection (SARI) threatens human health and even survival, causing a huge number of hospitalized patients every year. However, as one of the most common respiratory viruses circulated worldwide, the epidemiological and phylogenetic characteristics of human parainfluenza virus (HPIV) in these cases were not well known. OBJECTIVES To reveal the epidemiologica...
متن کاملImpact of supplementation with zinc and vitamin A in growth rate and morbidity of respiratory and diarrhea infections in infants
Introduction: Supplementation is a simple and effective intervention method in public health for control of parasite and infectious diseases in infants. The current study was conducted to determine the effect of supplementation with zinc and vitamin A in growth rate and morbidity of respiratory and diarrhea infections. Methods: In a randomized clinical trial, 628 infant between 6-60 month...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of infectious diseases
دوره 175 4 شماره
صفحات -
تاریخ انتشار 1997